Multiple hepatic tumors and peliosis hepatis in Fanconi's anemia treated with androgens

Am J Dis Child. 1977 Oct;131(10):1104-6.

Multiple hepatic tumors and peliosis hepatis in Fanconi's anemia treated with
androgens.

Shapiro P, Ikeda RM, Ruebner BH, Connors MH, Halsted CC, Abildgaard CF.

We report the case of a 13-year-old boy who was known to have Fanconi's anemia
for five years. For treatment of this condition he was given androgens and
corticosteroids. Two months before his death, severe varicella developed
complicated by pneumonia, jaundice, and prolonged fever; all of which resolved
during a five-week hospitalization. Three weeks later he died of Clostridium
septicum sepsis caused by necrotizing enterocolitis. At autopsy he was found to
have multiple hepatocellular neoplasms. A striking feature of the neoplasms was
cholestasis. The liver also showed peliosis hepatis. The association of the use
of certain androgenic steroids with hepatic neoplasms histologically resembling
hepatocarcinomas, but characterized by lack of metastases and apparent
reversibility, suggests the desirability of a new nomenclature for these
hepatocellular lesions.