Prevalence of the use of anabolic agents among strength training apprentices in Porto Alegre, RS

Arq Bras Endocrinol Metabol. 2007 Feb;51(1):104-10.

[Prevalence of the use of anabolic agents among strength training apprentices in
Porto Alegre, RS]

[Article in Portuguese]

Silva PR, Machado LC Jr, Figueiredo VC, Cioffi AP, Prestes MC, Czepielewski MA.

Faculdade de Medicina, UFRGS, RS.

This study aimed to determine through a questionnaire applied to interviewers,
the current or past use of anabolic androgenic steroids (AAS), as well as other
hormones (OH), and other medicines (OM), food supplement and illicit drugs among
strength training apprentices in the city of Porto Alegre, RS. We interviewed 288
subjects draw from a sample of 13 gyms. The prevalence of current and past use of
AAS was about 11.1% (32/288), OH 5.2% (16/288) and OM 4.2% (12/288). The most
used AAS were nandrolone and stanozolol; the OH were gonadotropin,
triiodothyronine (T3) and OM, like lipostabil, diuretics and veterinary medicines
(Monovin E). The most frequent side-effects were behavioral such as humor
oscillation, irritability and hostility, and endocrine disturbances such as acne
and increased or decreased libido. When analyzed together with other hormones in
a variable named "hormonal agents" (AH), AAS presented a statistical difference
(p< 0.05) among genders considering that the most frequent use of AH occurred
among men and those who consume food supplements. The comparison of these
findings to other national and international results is difficult due to the
epidemiological design. Even if it is considered, the observed prevalence
suggests that preventive attitudes as well as special care in the orientation and
education of this population must be taken.

Alteration of hormone levels in normal males given the anabolic steroid stanozolol.

Small M, Beastall GH, Semple CG, Cowan RA, Forbes CD.

Alteration of hormone levels in normal males given the anabolic steroid stanozolol.

Clin Endocrinol (Oxf). 1984 Jul;21(1):49-55.

ABSTRACT: Anabolic steroids have widespread metabolic effects but, to date, their proven clinical indications have been limited. Recently the 17 alpha-alkylated steroid, stanozolol, has been shown to be of value in a variety of commonly occurring vascular diseases. Its endocrine effects have received little attention and we have investigated the effect of administering a 14 d course of stanozolol (10 mg orally per day) on a variety of important hormonal pathways in nine healthy male subjects. Significant changes occurred as follows: a 55% reduction in serum testosterone levels was noted and was accompanied by reductions in 'derived' free testosterone, sex hormone binding globulin and LH levels; total T4 and T3 levels fell in association with a decrease in thyroxine binding globulin, but no alteration was detected in TSH or free T4 levels. Changes in vitamin D status, with falls in 25-hydroxycholecalciferol and vitamin D binding globulin were also observed. These effects were reversible on stopping treatment. Stanozolol therapy therefore leads to a number of hormonal changes, probably by an action at both pituitary and hepatic levels.