Effect of extended use of single anabolic steroids on urinary steroid excretion and metabolism

J Chromatogr. 1989 Apr 7;489(1):121-6.

Effect of extended use of single anabolic steroids on urinary steroid excretion
and metabolism.

Harrison LM, Martin D, Gotlin RW, Fennessey PV.

Department of Pediatrics, University of Colorado, Denver 80262.

Long-term use of single anabolic steroids by weightlifters and body builders at
dosages greater than or equal to 25 mg per 24 h resulted in reduced excretion of
urinary androgen metabolites, androsterone and etiocholanolone, compared to
values prior to anabolic use. The excretion of major urinary metabolites of
glucocorticoids was not affected by anabolic use. Urinary excretion of anabolic
steroids or anabolic metabolites averaged 20-25% of total anabolic steroid
administered. The major excreted metabolites of methandrostenolone, nandrolone,
oxandrolone and oxymetholone were identified by gas chromatography-mass
spectrometry based on the major mass spectral ion peaks.