Oxymetholone therapy in patients with familial antithrombin III deficiency

Thromb Haemost. 1988 Dec 22;60(3):495-7.

Oxymetholone therapy in patients with familial antithrombin III deficiency.

Shibuya A, Ninomiya H, Nakazawa M, Nagasawa T, Yoda Y, Abe T.

Division of Hematology, University of Tsukuba, Ibaraki, Japan.

Three patients with familial antithrombin III (ATIII) deficiency, who also have
histories of thromboembolism, were treated with oxymetholone in combination with
warfarin. Thrombolysis was observed in one patient with acute thrombosis of
inferior vena cava during the oxymetholone and warfarin therapy. No further
thromboembolic episodes occurred in these patients after initiation of warfarin
with or without oxymetholone. The levels of plasma ATIII, alpha 1-antitrypsin,
plasminogen and Cl-inactivator were significantly increased in all patients after
the introduction of oxymetholone therapy. This suggests that oxymetholone
augments anticoagulant and fibinolytic activity. Hence we consider that
oxymetholone in combination with warfarin may be possible thrombolytic therapy in