Hepatocellular carcinoma and squamous cell carcinoma in a patient with Fanconi's anemia

Ann Hematol. 1991 Jul;63(1):54-5.

Hepatocellular carcinoma and squamous cell carcinoma in a patient with Fanconi's
anemia.

Linares M, Pastor E, Gomez A, Grau E.

Department of Hematology, Hospital de Xátiva Lluis Alcanyis, Valencia, Spain.

Acute leukemia, hepatocellular carcinoma, and squamous cell carcinoma have been
reported in patients with Fanconi's anemia. We report on a 31-year-old woman who
developed squamous cell carcinoma of the esophagus and hepatocellular carcinoma.
Jaundice and hepatic tumor developed in 1981, after she had received oxymetholone
for 10 years. Liver biopsy revealed peliosis hepatis. Androgenic therapy was
stopped and the jaundice resolved. However, the hepatic tumor was observed to be
unchanged. The patient died of disseminated squamous cell carcinoma, but no
metastatic lesions from hepatocellular carcinoma were detected in the autopsy.
The association of Fanconi's anemia and squamous cell carcinoma is reviewed, and
the malignant potential of androgen-related hepatic tumors is discussed.