Induction of premature menstruation with catatoxic steroids

Am J Obstet Gynecol. 1971 Dec 15;111(8):1107-10.

Induction of premature menstruation with catatoxic steroids.

Bolch OH Jr, Warren JC.

PIP: The effects of spironolactone, diphenylhydantoin, oxymetholone, and
nandrolone phenproprionate, drugs which induce hepatic hydroxylase activity on
the menstrual cycle of healthy women from 21 to 39 years old, were studied. The 4
drugs were administered during the luteal phase of the menstrual cycle.
Diphenylhydantom and oxymetholone significantly shortened cycle length (p greater
than .001). The occurrance of ovulation was indicated by endometrial biopsies and
basal body temperature studies. Post nandrolone cycles were significantly longer
than control cycles (p greater than .05). Endometrial studies indicated that
ovulation occurred in the nandrolone and oxymetholone post treatment cycles. The
suggestion is made that these drugs might be used to terminate early pregnancy
and prevent pregnancy following sexual assault.