Hepatoma and peliosis hepatis developing in a patient with Fanconi's anemia.

N Engl J Med. 1971 May 20;284(20):1135-6.

Hepatoma and peliosis hepatis developing in a patient with Fanconi's anemia.

Bernstein MS, Hunter RL, Yachnin S.

PIP: Fanconi's anemia is a rare genetic disorder associated with congenital
deformities, infections, chromosomal abnormalities, and leukemia. This brief
article describes the case of a 20 year old man affected with the disease, who
was given 100 mg daily of oxymetholone to cure leukopenia and thrombocytopenia.
10 months later he died of hepatic failure. Autopsy revealed hepatoma and liver
peliosis, a rare condition of unknown etiology characterized by blood-filled
cysts in the liver. It is possible that in the case reported here the hepatoma
could have been related to the oxymetholone treatment, which conceivably could
have initiated hepatic damage.