South Med J. 1998 Aug;91(8):780-4.
Clenbuterol and anabolic steroids: a previously unreported cause of myocardial
infarction with normal coronary arteriograms.
Goldstein DR, Dobbs T, Krull B, Plumb VJ.
Department of Medicine, University of Alabama at Birmingham 35294-0007, USA.
During the last 10 years, several cases of myocardial infarction associated with
anabolic steroid use have been reported. Postulated mechanisms to explain this
association have included changes in lipid levels, the fibrinolytic system, and
platelet aggregation. Clenbuterol is a beta 2-agonist with anabolic properties
that has not been seen previously with myocardial infarction. We report a case of
myocardial infarction in an otherwise healthy 26-year-old body-builder who
recently used clenbuterol and anabolic steroids. In this case, synergistic
effects of the two agents seem likely to have played a role in the infarct. The
normal coronary arteriograms before any anticoagulant or thrombolytic therapy
strongly suggest coronary spasm as the mechanism of the infarct.
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