The -514 polymorphism in the hepatic lipase gene (LIPC) does not influence androgen-mediated stimulation of hepatic lipase activity.

J Lipid Res. 1998 Jul;39(7):1520-4.

The -514 polymorphism in the hepatic lipase gene (LIPC) does not influence
androgen-mediated stimulation of hepatic lipase activity.

Vega GL, Gao J, Bersot TP, Mahley RW, Verstraete R, Grundy SM, White A, Cohen JC.

The Center for Human Nutrition, Department of Clinical Nutrition, University of
Texas Southwestern Medical Center at Dallas, 75235, USA.

The -514T allele of hepatic lipase is associated with increased high density
lipoprotein-cholesterol levels in men, but not in women. This observation
suggests that the -514C to T polymorphism may diminish the response of hepatic
lipase to androgens. To test this hypothesis, five -514T and five -514C
homozygous men were treated with the anabolic steroid stanozolol for 6 days. The
mean increase in hepatic lipase activity was similar in the two groups (45+/-10
vs. 51+/-10 mmol x hr(-1) x l(-1), P = 0.5). To evaluate the association between
the -514 polymorphism and hepatic lipase activity at different physiological
androgen concentrations, hepatic lipase genotypes and activities were measured in
44 men and 40 premenopausal women. The effect of the -514T allele on hepatic
lipase activity was significant and quantitatively similar in both sexes. These
data indicate that the -514 polymorphism does not influence the response of
hepatic lipase activity to androgens, and that the effects of this polymorphism
on hepatic lipase activity are independent of androgen action.