Superior sagittal sinus thrombosis associated with androgen therapy for hypoplastic anemia

Ann Neurol. 1982 Dec;12(6):578-80.

Superior sagittal sinus thrombosis associated with androgen therapy for
hypoplastic anemia.

Shiozawa Z, Yamada H, Mabuchi C, Hotta T, Saito M, Sobue I, Huang YP.

Of 27 patients with hypoplastic anemia treated between 1971 and 1974 with male
hormone and protein-assimilating hormone, 3 developed superior sagittal sinus
thrombosis (SSST). The clinical symptoms and signs and angiographic findings of
SST were characteristic enough to allow an early diagnosis. Signs related to SST
were seizures, hemiplegia, facial palsy, stupor, and coma, with the most
important prodrome and consistent subjective complaint being headache. Following
discontinuation of the hormone therapy, neurological signs and symptoms related
to SSST gradually subsided. In all cases, the hematological picture improved with
discontinuation of the hormone therapies. It appears that administration of male
hormone can be associated with the development of SSST. If neurological symptoms
and signs of SSST appear, administration of the hormones should be discontinued.