Hereditary angioedema: modification of clinical manifestations with androgens.

Birth Defects Orig Artic Ser. 1976;12(6):283-7.

Hereditary angioedema: modification of clinical manifestations with androgens.

Davis PJ, Davis FB, Charache P.

HAE is an autosomal dominant trait of decreased levels or function of circulating
and tissue C'1 esterase inhibitor. The clinical illness is characterized by
disabling episodes of peripheral, oropharyngeal and gut-wall edema. Long-term
fluoxymesterone treatment of 5 affected males (393 patient-months) and
oxymetholone treatment of 6 affected females (204 patient-months) has
significantly decreased the frequency of attacks of edema without substantive
side effects.