Acquired aplastic anaemia in adults. II. Conventional treatment: retrospective study in 40 patients

Acta Haematol. 1977;58(6):339-52.

Acquired aplastic anaemia in adults. II. Conventional treatment: retrospective
study in 40 patients.

Haak HL, Hartgrink-Groeneveld CA, Guiot HF, Speck B, Eernisse JG, von Rood JJ.

The effect of conservative treatment of aplastic anaemia was evaluated
retrospectively in 40 patients. No significant beneficial effect was provided by
long-term high-dose oxymethalone in 20 patients or by metenolone, adrenstonolone,
or testosterone in 14 patients. Splenectomy gave no improvement in the majority
of cases, although in some it decreased the transfusion requirement.
Immunosuppressive treatment was successful in 1 patient with a positive LE
phenomenon. Until a specific treatment becomes available, the possibility offered
by alternative treatment, e.g. bone marrow transplantation, in cases with poor