J Allergy Clin Immunol. 1988 Aug;82(2):265-9.
The treatment of glucocorticosteroid-dependent chronic urticaria with stanozolol.
Brestel EP, Thrush LB.
Department of Medicine, West Virginia University School of Medicine, Morgantown.
In this study, four patients presented with chronic urticaria that required
glucocorticosteroid therapy for control. In the first patient, the urticaria
began during pregnancy and persisted after delivery with symptoms flaring
premenstrually thereafter. Danazol was selected in an attempt to suppress
progesterone levels, theoretically by inhibiting ovulation. The patient's
urticaria markedly improved, however, within 24 hours. Several months later, she
was switched to stanozolol with further improvement. Three other individuals were
treated with stanozolol with dramatic improvement. In all, three patients have
experienced the induction of five remissions (there were two recurrences), and
one patient remains much improved. All subjects have stopped both stanozolol and
glucocorticosteroids. Stanozolol appears to act synergistically with
glucocorticosteroids, and together, they may be capable of inducing remission in
some patients.
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