Contraception. 1975 Jun;11(6):669-76.
A study of the abortifacient effect of oxymetholone in early gestation.
Brenner PF, Mishell DR Jr.
PIP: Oxymetholone, a steroid which inhibits progesterone synthesis, was given to
6 women in early pregnancy to produce abortions. Patients were less than 7 weeks
pregnant; duration since last menstrual period was less than 46 days when therapy
started. Dosage varied from 50 mg daily for 7 days to 100 mg 3 times a day for 10
days. Serum HCG, progesterone, and estradiol levels were measured before, during,
and after therapy. Also total serum proteins, albumin, globulin, total bilirubin,
direct bilirubin, alkaline phosphatase, SGOT, SGPT, and complete blood counts
were obtained before and immediately after treatment. All determinations were
normal, including the hormones. No abortions resulted from the therapy although
some vaginal bleeding was noted by 3 patients. Nausea, vomiting, or abdominal
pain were side effects in 4. Results indicate that oxymetholone is an ineffective
agent for termination of early pregnancy.
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