Stanozolol causes rapid pain relief and healing of cutaneous ulcers caused by cryofibrinogenemia.

J Am Acad Dermatol. 1993 Jan;28(1):71-4.

Stanozolol causes rapid pain relief and healing of cutaneous ulcers caused by
cryofibrinogenemia.

Kirsner RS, Eaglstein WH, Katz MH, Kerdel FA, Falanga V.

Department of Dermatology and Cutaneous Surgery, University of Miami School of
Medicine, FL 33136.

BACKGROUND: Cutaneous manifestations of cryofibrinogenemia include purpura,
ecchymosis, and ulcerations. The histology of these lesions is characterized by
intravascular thrombi. OBJECTIVE: Our purpose was to test the efficacy of
stanozolol, a drug capable of fibrinolytic enhancement, in treating cutaneous
ulcers caused by cryofibrinogenemia. METHODS: Eight patients with cutaneous
ulcerations from cryofibrinogenemia were treated with stanozolol. Plasma
cryofibrinogen was measured before and during treatment with stanozolol.
Histologic evaluation was also performed before treatment and in selected
patients during treatment. RESULTS: After treatment, seven of the eight patients
had healing of their ulcers, prompt reduction in their pain, and improvement in
livedo reticularis and purpura. Four of the eight patients had no detectable
plasma cryofibrinogen after treatment. In addition, dermal intravascular thrombi
resolved. Stanozolol was well tolerated and had minimal side effects. CONCLUSION:
We conclude that stanozolol is a safe and effective treatment of the cutaneous
manifestations of cryofibrinogenemia.