Calcif Tissue Int. 1994 Jun;54(6):521-2.
Stanazolol--an anabolic steroid that does not influence parathyroid hormone
response to hypercalcemia in postmenopausal women.
Zofková I, Röjdmark S, Kancheva RL.
Institute of Endocrinology, Prague, Czech Republic.
Estrogen influences the calcium-induced suppressibility of parathyroid hormone
(PTH) in postmenopausal women. We tested the hypothesis that parathyroid gland
function is also sensitive to the anabolic steroid, stanazolol. The
calcium-induced suppressibility of PTH was investigated in 11 osteoporotic
postmenopausal women on two occasions, before and after 1 month's oral treatment
with stanazolol. Compliance to treatment was checked by the determination of
serum luteinizing hormone (LH) and testosterone. Serum intact PTH and ionized
calcium were estimated before and 5, 60, and 120 minutes after I.V. calcium load.
Calcium-induced PTH suppression was of a similar magnitude before and after
stanazolol, although calcium increments were identical. The results imply that
stanazolol--at biologically effective doses--does not affect PTH responsiveness
to hypercalcemia in postmenopausal women.
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