Pharmacol Biochem Behav. 2006 Mar;83(3):410-9. Epub 2006 Apr 17.
Stacking anabolic androgenic steroids (AAS) during puberty in rats: a
neuroendocrine and behavioral assessment.
Wesson DW, McGinnis MY.
The University of Texas at San Antonio, Department of Biology, 6900 North Loop
1604 West, San Antonio, TX 78249, USA.
Anabolic androgenic steroid (AAS) abuse is increasing in teenagers. We examined
the effects of stacked AAS in adolescent male rats. Stacking, in which multiple
AAS are taken simultaneously, is commonly employed by humans. Beginning at
puberty gonadally intact male rats received testosterone, nandrolone, or
stanozolol. Additional groups received stacked AAS: testosterone + stanozolol,
nandrolone + stanozolol, or nandrolone + testosterone. Injections continued
during tests for sexual behavior, vocalizations, scent marking, partner
preference, aggression and fertility. Body and reproductive tissue weights were
taken. Sexual and aggressive behaviors were increased by testosterone yet
inhibited by stanozolol; nandrolone had no effect. Stacking testosterone with
stanozolol prevented the inhibitory effects of stanozolol. Body weight was
decreased by testosterone and all stacked AAS. Cell nuclear androgen receptor
binding in brain was significantly increased in nandrolone males and decreased in
stanozolol males; testosterone males were slightly higher than controls. Androgen
receptors in stacked groups were intermediate between individual AAS suggesting
that stanozolol competed with other AAS for androgen receptors despite its low
affinity. The results indicate that stacking AAS influences the effects of
individual AAS on behavioral and endocrine measures, and levels of androgen
receptor occupation are not directly correlated with AAS effects on behavior.
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