Nonhealing ulcer secondary to factor V Leiden mutation and cryofibrinogenemia.

J Am Acad Dermatol. 2004 Nov;51(5 Suppl):S194-6.

Erratum in:
    J Am Acad Dermatol. 2004 Dec;51(6):1040.

Nonhealing ulcer secondary to factor V Leiden mutation and cryofibrinogenemia.

Barrio VR, Sanfilippo AM, Malone JC, Callen JP.

Department of Medicine, Division of Dermatology, University of Louisville School
of Medicine, Louisville, Kentucky 40202, USA.

Factor V Leiden is the most common genetic thrombophilia in people of European
descent, and is important to recognize as it can have significant implications in
dermatology. We report a case of a 30-year-old man who presented for evaluation
and treatment of a chronic ulceration on the site of his stump following a below
the knee amputation which had been performed for non-healing ulcerations. Despite
a variety of treatments, his ulcer persisted. He was referred to a dermatologist
who performed a biopsy that was interpreted ass non-specific, and treatment was
started for pyoderma gangrenosum. Further investigation revealed a homozygous
factor V Leiden mutation and cryofibrinogenemia. He was tapered off of the
methylprednisolone and was improving on stanozolol. He healed well after surgery
and no new ulcerations have developed. This case highlights the importance of
considering this mutation in a non-healing leg ulcer.