Hyperinsulinemia accompanying hyperglycemia in Chinese patients with aplastic anemia.

Am J Hematol. 1997 Nov;56(3):151-4.

Hyperinsulinemia accompanying hyperglycemia in Chinese patients with aplastic
anemia.

Kailin X, Yushu H, Qingchao W, Yuanbo L.

Institute of Hematology, Chinese Academy of Medical Sciences, Tianjin.
haoys@cdm.imicams.ac.cn

Serum insulin, and plasma glucagon and glucose levels were measured in 56 Chinese
patients with aplastic anemia (AA) and 40 normal controls. Serum insulin and
plasma glucose levels in 18 newly diagnosed cases and 11 previously treated cases
with prednisone were significantly higher than those in the controls. Serum
insulin and plasma glucose levels in 27 cases previously treated with stanozolol
were significantly higher than those in the newly diagnosed cases and the
previously treated cases with prednisone. There was no significant difference in
plasma glucagon levels between the patients and the controls. Serum insulin and
plasma glucose levels were significantly correlated with the amount of blood
transfusions and serum ferritin and cortisone concentrations in the AA patients.
Our findings suggest that AA patients may have hyperinsulinemia accompanying
hyperglycemia, which can be further aggravated by stanozolol and prednisone
therapy and iron overload.