Effects of short-term stanozolol administration on serum lipoproteins in hepatic lipase deficiency.

Metabolism. 1997 Sep;46(9):992-6.

Effects of short-term stanozolol administration on serum lipoproteins in hepatic
lipase deficiency.

Bausserman LL, Saritelli AL, Herbert PN.

Lipid Research Laboratory, Miriam Hospital, Brown University Medical School,
Providence, RI, USA.

We have identified a kindred in Providence, RI, deficient in hepatic triglyceride
lipase (HL). The two affected brothers have coronary heart disease and elevated
levels of triglycerides, total cholesterol, high-density lipoprotein (HDL)
cholesterol, and apolipoprotein [apo] A-I. The lipoprotein lipase (LPL) activity
is normal. We and others have postulated that the effects of oral anabolic
steroids on HDL metabolism are mediated by HL. To test this hypothesis, we
treated these two men and two controls with the oral androgen stanozolol (6 mg/d)
for 2 weeks. Consistent with other reports, HL activity increased a mean of 277%
in controls with a concomitant decrease in HDL cholesterol (49%), HDL2
cholesterol (90%), HDL3 cholesterol (16%), and apo A-I (41%) and no change in apo
A-II. Although stanozolol failed to induce HL activity in the HL-deficient man,
HDL cholesterol, HDL2 cholesterol, and apo A-I were reduced a mean of 20%, 48%,
and 32%, respectively. In contrast to controls, HDL3 cholesterol (46%) and apo
A-II (14%) increased in HL-deficient subjects. Stanozolol treatment also
increased LPL activity (124% +/- 86%, n = 4) and decreased lipoprotein(a)
([Lp(a)] 66% +/- 3%, n = 3) in the three men with detectable levels. The data
indicate that in addition to stimulation of HL activity, stanozolol treatment
changes HDL cholesterol concentration and subfraction distribution by other
mechanisms.