Lancet. 1975 Feb 22;1(7904):430-2.
Androgen-induced hepatoma.
Farrell GC, Joshua DE, Uren RF, Baird PJ, Perkins KW, Kronenberg H.
Three cases of hepatocellular carcinoma are reported in young men who had been
taking androgenic-anabolic steroids. The tumours were histologically similar to
those described in previous reports. The tumour progressed slowly in two patients
during four and seven years of observation, but in the latter bony metastases
occurred. In two patients the tumours regressed after administration of the drug
was discontinued. These cases strengthen the evidence that exogenous
androgenic-anabolic steroids may produce liver tumours. The use of these drugs
should be confined to serious conditions in which they are known to be effective.
Biochemical tests of liver function and serum alphs-fetoprotein estimation are
not useful as screening-tests for hepatoma in patients taking androgens, and
regular isotopic liver-scanning is recommended.
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