Anabolic steroid and gonadotropin releasing hormone analog combined treatment increased pubertal height gain and adult height in two children who entered puberty with short stature.

J Pediatr Endocrinol Metab. 2006 Sep;19(9):1125-31.

Anabolic steroid and gonadotropin releasing hormone analog combined treatment
increased pubertal height gain and adult height in two children who entered
puberty with short stature.

Satoh M, Yokoya S.

First Department of Pediatrics, Toho University School of Medicine, Japan.
satomari@med.toho-u.ac.jp

We studied the effect of gonadal suppression treatment in combination with
anabolic steroid on pubertal height gain and adult height in two children who
entered puberty with short stature. Patient 1 was a female with idiopathic short
stature. She received combined treatment with an anabolic steroid (stanozolol)
and a gonadotropin releasing hormone analog (leuprorelin acetate). Her pubertal
height gain was 28.5 cm, which is greater than that in normal height girls (20-25
cm). Patient 2 was a male with Aarskog syndrome. Although his growth hormone (GH)
secretion was normal, he received GH treatment. Since GH administration did not
accelerate his growth, he received combined treatment with stanozolol and
leuprorelin acetate. His pubertal height gain was 27.0 cm, which is greater than
that observed in GH deficient boys treated with GH alone (21.9 cm). Combined
treatment with stanozolol and leuprorelin acetate appears to be effective in
increasing pubertal height gain and adult height in children who enter puberty
with short stature.