Regression on oxymetholone-induced hepatic tumors after bone marrow transplantation in aplastic anemia

Transplantation. 1980 Aug;30(2):90-6.

Regression on oxymetholone-induced hepatic tumors after bone marrow
transplantation in aplastic anemia.

Montgomery RR, Ducore JM, Githens JH, August CS, Johnson ML.

Treatment of acquired aplastic anemia with androgens has been occasionally
associated with the development of hepatic tumors. We have studied a 13-year-old
boy with idiopathic aplastic anemia in whom oxymetholone treatment was associated
with a partial hematological remission. Thirty-four months later, however, the
patient developed multiple hepatic tumors. When oxymetholone therapy was
discontinued, the aplastic anemia relapsed. He then underwent bone marrow
transplantation from his HLA-A, B, and D-compatible sibling. This was followed by
hematological and immunological reconstitution. The hepatic tumors underwent
progressive regression after bone marrow transplantation. The patient is now 3
years post-bone marrow transplantation and is in complete remission of his
aplastic anemia with no evidence of detectable liver tumors.