Schweiz Med Wochenschr. 1979 Sep 29;109(37):1384-5.
[Immunosuppression, bone marrow infusion and low dose androgens, successful
therapy of severe aplastic anemia]
[Article in German]
Cornu P, Speck B, Gratwohl A, Nissen C, Sartorius J, Jeannet M.
18 patients with severe aplastic anemia (SAA) but without an HLA-identical
sibling were treated by antilymphocyte globulin (ALG) followed by infusion of
marrow cells from a semi-compatible family donor. 13 of these received low dose
androgens after ALG: 11 (85%) achieved stable remission without transfusion
requirement. One patient relapsed after 4 months, one patient with only partial
remission died from infection. None of the 4 patients who did not receive
androgens after ALG achieved remission. ALG, marrow and low-dose androgens
represent a promising therapy for SAA and can be favorably compared with
allogeneic bone marrow transplantation.
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